แผลเบาหวาน แผลกดทับ เอนไซม์แก้ไขได้: เรียนเชิญร่วม Work Shop ประจำเดือน มีนาคม 2551

MRSA แผลติดเชื้อรุนแรง แผลไฟไหม้-น้ำร้อนลวก แผลเบาหวาน แผลกดทับ เอนไซม์แก้ไขได้

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จากโปรตีนธรรมชาติ...
ด้วยคุณสมบัติพิเศษของโปรตีนธรรมชาติ Lysostaphin+Lysozyme,

Lysostaphin มีฤทธิ์ต่อต้านเชื้อแบคทีเรียได้อย่างมีประสิทธิภาพ และเฉียบพลันไม่ระคายเคือง เพราะเป็นโปรตีนธรรมชาติ

Lysozyme มีฤทธิ์ย่อยสลายโปรตีนของแบคทีเรีย ช่วยลอกเซลล์ที่ตายออก พร้อมช่วยฟื้นฟูการสร้างเซลล์ผิวใหม่ ไม่ระคายเคือง เพราะเป็นโปรตีนธรรมชาติ แตกต่างจากการใช้สารเคมี

สนใจเพิ่มเติม คลิกที่นี่

วันพุธที่ 19 มีนาคม พ.ศ. 2551

เรียนเชิญร่วม Work Shop ประจำเดือน มีนาคม 2551

Dear All Guests,
We would like to invite you to participate
"New Innovation with New Biological world".
The event held on 31 March 08
at Bhaisakkuekuol (BSK)

Agenda
17:00 pm. Register

17:30 pm. section One Introduction and Overview of Enzyme world presented by Dr.Assadang Polnok
The Head department of Faculty of Pharmaceutical Engineering University Naresuan.

18:30 pm. Discussion

PS: Parking check with Security Guard at the front

Call for Reservation please contack : Khun Vill 086 6046810

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มารู้จักบางสิ่งที่ดูเหมือนไกลตัว แต่อันที่จริงอยู่ใกล้แต่จมูกของเรา

Chicken egg white Lysozyme

Lysozyme is 129 aminoacid residues enzyme (EC 3.2.1.17) which catalyzes hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Molecular weight of Lysozyme is an approximately 14.7 kDa. Alternative name for Lysozyme are 1,4-N-acetylmuramidase, L-7001, N,O-diacetylmuramidase, PR1-Lysozyme, Globulin G1, Globulin G, Lysozyme g, Mucopeptide N-acetylmuramoylhydrolase, Mucopeptide glucohydrolase and Muramidase. This catalytic activity is non-specifically targeted to the bacterial cell membranes and related with general non-specific organism defence.

Lysozyme is present in the mucosal secretion such as saliva and tears. In high concentration, about 3% from all proteins, Lysozyme is present in chicken egg-white. This enzyme is only effective against Gram positive bacterial cells. Gram negative bacteria and yeast are completely resistant to lysing by it.

Historically, Lysozyme was discovered in 1922 by Alexander Fleming (Fleming A. (1922) On a remarkable becteriolytic element found in tissues and secretion. Proc Roy Soc Ser B, 93, 306-317.). This enzyme was discovered by accident, which was happen in the Fleming's lab. The nasal drippings were accidentally occurring in the petre dish with bacterial culture and these cells were lysed. This phenomenon was carefully investigated and the main acting enzyme was identified as Lysozyme.

In 1965 the structure of Lysozyme was solved by X-Ray analysis with 2 angstrom resolution by David Chilton Phillips. For many years Lysozyme was the best object for X-Ray analysis due to many unique properties of this enzyme. First of all Lysozyme is easy to purify from egg-white. Secondly, this protein is very easy to crystallize, which is not the case for most of the other proteins. This feature of Lysozyme is widely used for it purification. And finally, crystals of Lysozyme diffract X-Ray beam to a very high resolution, currently the highest resolution structure, presented in Protein Data Bank, was solved at resolution 0.94 Angstrom.

In viruses (or bacteriophages), Lysozyme is used as an agent to break into the host bacterial cell. Lysozyme from the tail of the virus (or bacteriophage) destroys the peptidoglycan bacterial cell wall and then virus can injects its DNA. After multiplication in bacteria, many Lysozyme molecules are created to lyse the bacterial cell wall and release new viruses.

Next: Lysozyme Mechanism

Lysozyme

September 2000 Molecule of the Month
by David S. Goodsell
Previous Features

Attacking Bacteria

Lysozyme protects us from the ever-present danger of bacterial infection. It is a small enzyme that attacks the protective cell walls of bacteria. Bacteria build a tough skin of carbohydrate chains, interlocked by short peptide strands, that braces their delicate membrane against the cell's high osmotic pressure. Lysozyme breaks these carbohydrate chains, destroying the structural integrity of the cell wall. The bacteria burst under their own internal pressure.

The First Antibiotic

Alexander Fleming discovered lysozyme during a deliberate search for medical antibiotics. Over a period of years, he added everything that he could think of to bacterial cultures, looking for anything that would slow their growth. He discovered lysozyme by chance. One day, when he had a cold, he added a drop of mucus to the culture and, much to his surprise, it killed the bacteria. He had discovered one of our own natural defenses against infection. Unfortunately, lysozyme is a large molecule that is not particularly useful as a drug. It can be applied topically, but cannot rid the entire body of disease, because it is too large to travel between cells. Fortunately, Fleming continued his search, finding a true antibiotic drug five years later: penicillin.

A Cellular Guardian

Lysozyme protects many places that are rich in potential food for bacterial growth. The lysozyme pictured here is from hen egg whites, where it serves to protect the proteins and fats that will nourish the developing chick. It was the first enzyme ever to have its structure solved--you can find it in PDB entry 2lyz. Our tears and mucus contain lysozyme to resist infection of our exposed surfaces. Our blood is the worst place to have bacteria grow, as they would be delivered to all corners of the body. In the blood, lysozyme provides some protection, along with the more powerful methods employed by the immune system.

Staphylococcus

Staphylococcus

Once MRSA was just a simple germ

Staphylococcus - A genus of spherical bacteria of the family Micrococcaceae, is the best known species of which are universally present in very great numbers, on the mucous membranes and skin of humans, and some other warm-blooded animals. The term staphylococcus, generally used for all the species, refers to the cell's habit of assembling in grapelike clusters. Staph, is a commonly used slang name for this bug.

COPYRIGHT - Dennis Kunkel Microscopy, Inc.

Staphylococci are microbiologically characterized as gram-positive - in young cultures, and non-spore-forming, non-motile, facultative anaerobes - not requiring oxygen.

The cells average 1 μm - micrometer; 1 μm = 0.00l mm, in diameter and are usually clustered.

Micrometer - also called Micron, metric unit of measure for length equal to 0.00l mm, or about 0.000039 inch. Its symbol is μm, or one millionth of a meter. The micrometer is commonly employed to measure the thickness or diameter of microscopic objects, such as microorgaisms and colloidal particles. Minute distances, as, for example, the wavelengths of infrared radiation, are also given in micrometers.

Significant to humans, are two variants of the species Staphylococcus. Aureus, an important agent of wound infections, boils, pustules, and other human skin infections, and one of the most common causes of food poisoning. Staphylococcus. Aureus, also causes udder inflammation, or mastitis, in domestic animals and breast infections in women.

It has become a difficult hospital pathogen because of its resistance to antibiotics. Staphylococcus. Aureus epidermis is a milder pathogen that is opportunistic in persons with lowered resistance. Many strains of Staphylococcus Aureus are now resistant to penicillin. This is because Staphylococcus Aureus has evolved or mutated, simply by accident, to make a substance called ß-lactamase - pronounced beta-lactamase, that degrades penicillin, destroying its antibacterial activity. Tests done on any Staphylococcus Aureus grown from such specimens can then decide how sensitive the organisms is to antibiotics and if it is a Methicillin resistant (MRSA) organism. These test usually take 2-3 days.

Bactericidal - Bactericides - Capable of killing bacteria. Common bactericides are some antibiotics, antiseptics, and disinfectants. many cleaning products are sold, that claim or state to kill all or 99% of all known germs. There are many antibiotics, antiseptics, and disinfectants that will readily kill bacteria, but may also kill or damage the host you wish to cure. Bleach will kill 99.9% of all known micro-organisms but will also kill any person who hosts the germs, you want to attack.

Aerobic bacteria, Staphylococcus aureus, cultured on an agar plate for drug sensitivity test in an anaerobic environment. The toxin produced by Staphylococcus aureus causes the illness "staphylococcal intoxication". Symptoms of this intoxication include nausea, vomiting, and diarrhea.
Gram-Positive Bacterial Infections, Staphylococcal Infections

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MRSA แผลติดเชื้อรุนแรง แผลไฟไหม้-น้ำร้อนลวก แผลเบาหวาน แผลกดทับ เอนไซม์แก้ไขได้

วันพุธที่ 19 มีนาคม พ.ศ. 2551

เรียนเชิญร่วม Work Shop ประจำเดือน มีนาคม 2551

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แผลเบาหวาน แผลกดทับ เอนไซม์แก้ไขได้

www.lysocare.com

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Enzyme

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MRSA เราควรรู้จัก

แผลติดเชื้อรุนแรง อาทิ แผลกดทับ แผลเบาหวาน แผลไฟไหม้ และอื่นๆ

แผลติดเชื้อรุนแรง อาทิ แผลกดทับ แผลเบาหวาน แผลไฟไหม้ และแผลติดเชื้ออื่นๆ

Staphylococcus aureus

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